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Dmd051409 1174..1178
Mdr1a-, Bcrp-, and Mrp2-knockout rats are a more practical species for absorption, distribution, metabolism, and excretion (ADME) studies than murine models and previously demonstrated expected alterations in the pharmacokinetics of various probe substrates. At present, gene expression and pathology changes were systematically studied in the small intestine, liver, kidney, and brain tissue from...
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vascular diseases. Interest of many authors has been to isolate laboratory values associated with a high risk of the onset or worsening of clinical coronary artery disease. Afterwards, a possible link of these values with chronic infection carrier status was sought. Many conditions related with vascular pathology, such as hypercoagulability, presence of circulating immune complexes and oxidativ...
متن کاملDmm023036 1171..1174
Model systems, including laboratory animals, microorganisms, and celland tissue-based systems, are central to the discovery and development of new and better drugs for the treatment of human disease. In this issue, Disease Models & Mechanisms launches a Special Collection that illustrates the contribution of model systems to drug discovery and optimisation across multiple disease areas. This co...
متن کاملDmd051409 1174..1178
Mdr1a-, Bcrp-, and Mrp2-knockout rats are a more practical species for absorption, distribution, metabolism, and excretion (ADME) studies than murine models and previously demonstrated expected alterations in the pharmacokinetics of various probe substrates. At present, gene expression and pathology changes were systematically studied in the small intestine, liver, kidney, and brain tissue from...
متن کاملDmd051409 1174..1178
Mdr1a-, Bcrp-, and Mrp2-knockout rats are a more practical species for absorption, distribution, metabolism, and excretion (ADME) studies than murine models and previously demonstrated expected alterations in the pharmacokinetics of various probe substrates. At present, gene expression and pathology changes were systematically studied in the small intestine, liver, kidney, and brain tissue from...
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ژورنال
عنوان ژورنال: The Iowa Review
سال: 1975
ISSN: 0021-065X,2330-0361
DOI: 10.17077/0021-065x.1854